Host institution: Fundación del Sector Público Estatal Centro Nacional de Investigaciones Oncológicas Carlos III, Madrid, Spain
Host department: Microenvironment & Metastasis Group
Supervisor: Dr. Hector Peinado
Project description
Our laboratory is specialized in the in vivo analysis of exosomes delivery by in vivo imaging and characterization of exosomes by proteomics. We have recently described that specific signatures can be tracked in circulation and are representative of the progression of the disease (Peinado, Nat. Med 2012, Costa-Silva Nat Cell Biol 2015, Hoshino et al. Nature 2015). Currently, we are analysing the role of exosomes in lymph node premetastatic niche formation and main cell types involved. This project will be focused on the analysis of pre-metastatic niche formation in the lymph nodes by prostate cancer. We will analyze biodistribution of tumor-derived exosomes, main cells uptaking exosomes in lymph nodes and mechanism involved in local and distal metastasis.
Type of contract
Fixed-term position for 36 months
Full-time, 37.5 hrs per week
Required expertise and skills in addition to the general eligibility criteria
Candidate should have experience in laboratory for at least one year with knowledge of molecular laboratory techniques (e.g. confocal microscopy, flow cytometry, cell culture, use of mouse models, CRISPR-CAS9 technology). Experience abroad in laboratories will be positively considered. Assistance to conferences and courses will be positively considered.
Website
Research group Peinado: https://www.cnio.es/investigacion-e-innovacion/programas-cientificos/programa-de-oncologia-molecular/grupo-de-microambiente-y-metastasis/
Contact details
For more information about this position, please contact:
Dr. Hector Peinado: hpeinado@cnio.es
